Omega-3 Fish Oil May Reduce Seizure Frequency for People with Epilepsy

Omega-3 Fish Oil May Reduce Seizure Frequency for People with Epilepsy

Approximately 2.3 million adults and around 470,000 children in the US have epilepsy, a lifelong neurological condition characterized by recurrent seizures. Now, a new study claims epilepsy patients could reduce seizure frequency by consuming low doses of omega-3 fish oil every day.

The research team, led by Prof. Christopher DeGiorgio of the Department of Neurology at the University of California-Los Angeles (UCLA) School of Medicine, says their findings may be particularly useful to epilepsy patients who no longer respond to medication.

They publish their findings in the Journal of Neurology, Neurosurgery & Psychiatry.

Omega-3 fatty acids can be obtained through consumption of oily fish – such as a trout, mackerel, tuna, herring, sardines and salmon – and fish oil supplements.

Past studies have indicated omega-3 can stabilize heart rhythm and prevent heart attacks. Prof. DeGiorgio says this is important for individuals with epilepsy since they are at higher risk of heart attack than those who do not have the condition. Furthermore, the team notes that omega-3 has been linked to reduced brain cell excitability among epileptics, which may curb seizures.

However, they point out that previous studies looking at such associations using high-dose fish oil have been inconclusive.

As such, the team set out to determine the effects of high-dose and low-dose fish oil on the cardiovascular health and seizure frequency of epileptic patients.

Low-dose fish oil supplementation ‘reduced seizures by more than 30%’

For their study, the researchers enrolled 24 participants with epilepsy who had stopped responding to antiepileptic medication.

Each patient was subject to three different supplementation regimes, each of which lasted for 10 weeks and were divided by a 6-week period. These were:

  • Low-dose fish oil supplementation: three fish oil supplements daily – the equivalent of 1,080 mg of omega-3 – plus three placebo supplements (corn oil)
  • High-dose fish oil supplementation: six fish oil supplements daily – the equivalent of 2,160 mg of omega-3
  • Three placebo supplements twice a day.

The researchers found that the fewest number of seizures occurred – 12 a month – when participants were following the low-dose fish oil regime, compared with 17 a month on the high-dose regime and around 18 a month for the placebo regime. This means the low-dose regime represented a 33.6% reduction in seizures.

The team also found that two of the patients following the low-dose fish oil regime had no seizures at all during the 10-week trial, while none of the patients taking high-dose fish oil or placebos were seizure-free.

Furthermore, blood pressure fell by 1.95 mm/Hg among patients following the low-dose fish oil regime, while high-dose fish oil was linked to an increase of 1.84 mm/Hg in blood pressure.

The team notes, however, that they found no link between fish oil and severity of seizures, changes in heart rate or blood lipid levels.

The primary finding is that low-dose fish oil was associated with a reduction in seizure frequency of 33.6% compared with placebo. Though the size of the trial will require confirmation, the magnitude of the effect on seizure frequency is similar to many randomized trials of antiepileptic drugs.

The reduction in blood pressure indicates that low-dose fish oil may exert a positive cardiovascular benefit in this cohort with drug-resistant epilepsy, a finding of some importance, given the recent data that the risk of death due to myocardial infarction is significantly higher in people with epilepsy.”

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