Improved Access to Genomic Data Empowers Clinical Teams to Understand the Causes of a Person’s Epilepsy and Develop Personalized Care
Researchers from the HSE Epilepsy Lighthouse Project and FutureNeuro, the SFI Research Centre for Chronic and Rare Neurological Diseases hosted by RCSI, have developed a new genomics module in the Irish National Epilepsy Electronic Patient Record (EPR) system.
The work illustrates how an electronic health system can support the integration of genomic test results and new genetic knowledge into routine clinical care in the public health system. This new system will facilitate more personalized forms of medicine.
The research, funded by eHealth Ireland, the Health Service Executive (HSE) and Science Foundation Ireland, is published in the latest issue of the journal Epilepsia.
Many adults and children with epilepsy of unknown cause now undergo genomic testing. An accurate genetic diagnosis can bring great value to the individual, their family, and the clinical team. As a result of this research, many people now understand why they have epilepsy. For some, this has been a decade’s long journey of multiple treatments and no explanation or knowledge of the actual underlying cause for their condition.
“We now know that much of previously unexplained epilepsy is due, in part, to damaging variants in a person’s genome,” said Prof. Norman Delanty, Associate Professor at RCSI, FutureNeuro Investigator and Consultant Neurologist at Beaumont Hospital.
“The potential to understand the reason for a particular person’s epilepsy at a molecular level, and to use this information to develop personalized therapies will become a significant advancement in the way we practice medicine.”
Ireland has a world-leading national EPR system designed specifically for epilepsy. This system captures, in great depth, the subtle patient features relevant to specialist care and allows for quicker access to key clinical data to better support people with complex chronic diseases such as epilepsy.
In 2015, the HSE and eHealth Ireland designated the national Epilepsy EPR as a “Lighthouse” project for the country to help build an understanding of the quality, safety, and efficiency benefits of EPRs. The Lighthouse project combined the emerging fields of genomics and EPRs to promote personalized medicine and improved healthcare for people with epilepsy.
“The epilepsy EPR system is one of the largest, most detailed collections of active epilepsy eHealth records in the world,” said Mary Fitzsimons, FutureNeuro Epilepsy eHealth Lead and Director of the Epilepsy Lighthouse Project at RCSI. “To our knowledge, the epilepsy genomics module we have developed is the first such specific system in the world. We believe the combined power of genomics and electronic patient records has the capability of enhancing, and in some cases transforming, the practice of medicine.”
The new Epilepsy EPR module facilitates regular multidisciplinary meetings between clinicians, geneticists, bioinformaticians, and other team members, where they review data from genomic testing to determine if there is an identifiable genetic cause for a person’s epilepsy.
“Diagnostic genomic testing is a rapidly growing area in clinical medicine, but there is much work to be done to understand the most effective way to integrate this powerful information into patient care.
We hope this new eHealth technology can inform how genomics is integrated into the Irish healthcare system and act as an example for other diseases beyond epilepsy,” said Gianpiero Cavalleri, FutureNeuro Deputy Director and Professor of Human Genetics at RCSI. “Having this data available in a person’s secure electronic record enables multidisciplinary teams to quickly make better decisions about a person’s treatment options.”
FutureNeuro researchers will continue to work with multidisciplinary teams in Irelands leading hospitals and people affected by neurological diseases to enhance the EPR to develop more personalized care.
FutureNeuro is a new SFI Research Centre dedicated to developing new technologies and solutions for the treatment, diagnosis, and monitoring of chronic and rare neurological diseases. It is supported by Science Foundation Ireland. Initially focusing on Epilepsy and Motor Neuron Disease, FutureNeuro will build rapidly to help transform the lives of the approximately 800,000 people affected by neurological disorders in Ireland.
It connects national and multinational industry with key academics and clinicians based in our leading hospitals to provide diagnostic, therapeutic and E-Health solutions. FutureNeuro’s projects with industry partners will bring diagnostic supports to market, a pipeline of new drugs, and connected health solutions that enable patients to monitor and report their health better than ever before.